GENERATION OF NOVEL IN VITRO FLEXIBLE KIDNEY ORGANOID MODEL TO INVESTIGATE THE ROLE OF EXTRACELLULAR VESICLES IN INDUCTION OF NEPHROGENESIS

Generation of novel in vitro flexible kidney organoid model to investigate the role of extracellular vesicles in induction of nephrogenesis

Abstract Background During kidney organogenesis, metanephric herco guitar humidifier mesenchyme (MM) and ureteric bud (UB) interact reciprocally to form nephrons.Signaling stimuli involved in these interactions include Wnts, growth factors and nano/micro particles.How UB and MM are interacting is not completely understood.Our study investigated the

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Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility.

Fanconi Anemia (FA) is a genomic instability syndrome resulting in aplastic anemia, developmental abnormalities, and predisposition to hematological and other solid organ malignancies.Mutations in genes that encode proteins of the FA pathway fail to orchestrate the repair of DNA damage caused by DNA interstrand crosslinks.Zebrafish harbor homologs

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Using geolocator tracking data and ringing archives to validate citizen-science based seasonal predictions of bird distribution in a data-poor region

Unstructured citizen-science data are increasingly used for analysing the abundance and distribution of species.Here we test the usefulness of such data to predict the seasonal distribution of migratory songbirds, and to analyse patterns of migratory connectivity.We herco guitar humidifier used bird occurrence data from eBird, one of the largest gl

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